| Name | TC-S 7009 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5240 |
| Prices | $139.00, $579.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1422955-31-4 |
| Chemical Name | N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine |
| Formula | C12H6ClFN4O3 |
| Molecular Weight | 308.65 |
| Purity | >99 % |
| Description | High affinity and selective HIF-2 α inhibitor (K d = 81 nM). Binds to the HIF-2 α PAS-B domain; disrupts HIF-2 α -ARNT heterodimerization. Exhibits >60-fold selectivity for HIF-2 α over HIF-1 α . Decreases HIF-2 α DNA-binding and attenuates expression of HIF-2 α target genes in vitro . |
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Rogers JL, Bayeh L, Scheuermann TH, Longgood J, Key J, Naidoo J, Melito L, Shokri C, Frantz DE, Bruick RK, Gardner KH, MacMillan JB, Tambar UK. J Med Chem. 2013 Feb 28;56(4):1739-47.
Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH, Bruick RK. Nat Chem Biol. 2013 Apr;9(4):271-6.