TC-S 7010

• Supplier: Tocris Bioscience
• Catalog: 5243
• Prices: $205.00, $845.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1158838-45-9
• Chemical Name: N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide
• Formula: C31H31ClFN7O2
• Molecular Weight: 588.07
• Purity: >99 %
• Description: Potent and selective inhibitor of Aurora kinase A (IC 50 = 3.4 nM); exhibits 1000-fold selectivity for Aurora kinase A over Aurora kinase B. Displays antiproliferative activity in HCT116 and HT29 cells (IC 50 values are 0.19 and 2.9 μ M respectively).

Product References

A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high - A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high

Aliagas-Martin I, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Huang OW, Hunsaker T, Kleinheinz T, Krueger E, Liang J, Moffat J, Phillips G, Pulk R, Rawson TE, Ultsch M, Walker L, Wiesmann C, Zhang B, Zhu BY, Cochran AG. J Med Chem. 2009 May 28;52(10):3300-7.

Overcoming CML acquired resistance by specific inhibition of Aurora A kinase in - Overcoming CML acquired resistance by specific inhibition of Aurora A kinase in

Yuan H, Wang Z, Zhang H, Roth M, Bhatia R, Chen WY. Carcinogenesis. 2012 Feb;33(2):285-93.