| Name | TCS JNK 6o |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2827 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 894804-07-0 |
| Chemical Name | N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide |
| Formula | C18H20N4O4 |
| Molecular Weight | 356.38 |
| Purity | >98 % |
| Description | ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor (IC 50 values are 2, 4 and 52 nM for JNK1, JNK2 and JNK3 respectively). Displays > 1000 fold selectivity over other kinases, including ERK2 and p38. Inhibits c-Jun phosphorylation (EC 50 = 920 nM) and prevents collagen-induced platelet aggregation in vitro . |
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Szczepankiewicz BG, Kosogof C, Nelson LT, Liu G, Liu B, Zhao H, Serby MD, Xin Z, Liu M, Gum RJ, Haasch DL, Wang S, Clampit JE, Johnson EF, Lubben TH, Stashko MA, Olejniczak ET, Sun C, Dorwin SA, Haskins K, Abad-Zapatero C, Fry EH, Hutchins CW, Sham HL, Rondinone CM, Trevillyan JM. J Med Chem. 2006 Jun 15;49(12):3563-80.
Kauskot A, Adam F, Mazharian A, Ajzenberg N, Berrou E, Bonnefoy A, Rosa JP, Hoylaerts MF, Bryckaert M. J Biol Chem. 2007 Nov 2;282(44):31990-9. Epub 2007 Sep 4.