TCS OX2 29

• Supplier: Tocris Bioscience
• Catalog: 3222
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 372523-75-6
• Chemical Name: (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride
• Formula: C23H31N3O3.HCl
• Molecular Weight: 433.97
• Purity: >98 %
• Description: Potent and selective OX 2 receptor antagonist (IC 50 = 40 nM). Displays >250-fold selectivity for OX 2 over OX 1 and a range of receptors, ion channels and transporters. Inhibits orexin A induced IP 3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX 2 receptor.

Product References

N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor - N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor

Hirose M, Egashira S, Goto Y, Hashihayata T, Ohtake N, Iwaasa H, Hata M, Fukami T, Kanatani A, Yamada K. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4497-9.

Binding kinetics differentiates functional antagonism of orexin-2 receptor - Binding kinetics differentiates functional antagonism of orexin-2 receptor

Mould R, Brown J, Marshall FH, Langmead CJ. Br J Pharmacol. 2014 Jan;171(2):351-63.