Telmisartan

• Supplier: Tocris Bioscience
• Catalog: 1122
• Prices: $79.00, $335.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 144701-48-4
• Chemical Name: 4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylicacid
• Formula: C33H30N4O2
• Molecular Weight: 514.62
• Purity: >99 %
• Description: Antagonist of the angiotensin II type 1 receptor (AT 1 ) (K i = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPAR γ receptors; shown to improve insulin sensitivity in rodents receiving high fat diets.

Product References

6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor - 6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor

Ries UJ, Mihm G, Narr B, Hasselbach KM, Wittneben H, Entzeroth M, van Meel JC, Wienen W, Hauel NH. J Med Chem. 1993 Dec 10;36(25):4040-51.

Identification of telmisartan as a unique angiotensin II receptor antagonist with - Identification of telmisartan as a unique angiotensin II receptor antagonist with

Benson SC, Pershadsingh HA, Ho CI, Chittiboyina A, Desai P, Pravenec M, Qi N, Wang J, Avery MA, Kurtz TW. Hypertension. 2004 May;43(5):993-1002. Epub 2004 Mar 8.

An adipose tissue-independent insulin-sensitizing action of telmisartan: a study - An adipose tissue-independent insulin-sensitizing action of telmisartan: a study

Rong X, Li Y, Ebihara K, Zhao M, Aini W, Kusakabe T, Hirata M, Miyamoto L, Murray M, Nakao K. J Pharmacol Exp Ther. 2009 Dec;331(3):1096-103.