Temozolomide

• Supplier: Tocris Bioscience
• Catalog: 5139
• Prices: $89.00, $375.00
• Sizes: 10 mg, 50 mg
• Cas Number: 85622-93-1
• Chemical Name: 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide
• Formula: C6H6N6O2
• Molecular Weight: 194.15
• Purity: >99 %
• Description: DNA methylating, chemotherapeutic agent. Displays antitumor activity against a board spectrum of tumors, including leukemias, lymphomas and solid tumors (IC 50 = 5.0 μ M for cytotoxicity against mouse TLX5 lymphoma cells). Induces autophagy in malignant glioma cells. Exhibits enhanced activity when used in combination with CHC (Cat No. 5029).

Product References

Preclinical antitumor activity of temozolomide in mice: efficacy against human - Preclinical antitumor activity of temozolomide in mice: efficacy against human

Plowman J, Waud WR, Koutsoukos AD, Rubinstein LV, Moore TD, Grever MR. Cancer Res. 1994 Jul 15;54(14):3793-9.

Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and - Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and

Clark AS, Deans B, Stevens MF, Tisdale MJ, Wheelhouse RT, Denny BJ, Hartley JA. J Med Chem. 1995 Apr 28;38(9):1493-504.

Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma - Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma

Kanzawa T, Germano IM, Komata T, Ito H, Kondo Y, Kondo S. Cell Death Differ. 2004 Apr;11(4):448-57.