Temsirolimus

• Supplier: Tocris Bioscience
• Catalog: 3082
• Prices: $149.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 162635-04-3
• Chemical Name: Rapamycin42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate]
• Formula: C56H87NO16
• Molecular Weight: 1030.29
• Purity: >98 %
• Description: mTOR inhibitor; inhibits tumor growth in breast cancer cell lines (IC 50 values are 1.6 and 4.3 nM for SKBr3 and BT474, respectively). Inhibits HIF-1 α -mediated VEGF production in breast cancer cell lines (BT474 and MDA-MB-231). Directly inhibits serum and VEGF mediated endothelial cell proliferation and morphogenesis in vitro and vessel formation in vivo . Causes G 1 /S cell cycle arrest in multiple cancer cell lines. Antiangiogenic.

Product References

Effects of the mammalian target of rapamycin inhibitor CCI-779 used alone or with - Effects of the mammalian target of rapamycin inhibitor CCI-779 used alone or with

Wu L, Birle DC, Tannock IF. Cancer Res. 2005 Apr 1;65(7):2825-31.

Antiangiogenic potential of the Mammalian target of rapamycin inhibitor - Antiangiogenic potential of the Mammalian target of rapamycin inhibitor

Del Bufalo D, Ciuffreda L, Trisciuoglio D, Desideri M, Cognetti F, Zupi G, Milella M. Cancer Res. 2006 Jun 1;66(11):5549-54.

Inhibition of mammalian target of rapamycin signaling by CCI-779 (temsirolimus) - Inhibition of mammalian target of rapamycin signaling by CCI-779 (temsirolimus)

Wang Z, Liu T, Chen Y, Zhang X, Liu M, Fu H, Liu D. DNA Cell Biol. 2012 Jun;31(6):1095-9.

The novel mTOR inhibitor CCI-779 (temsirolimus) induces antiproliferative effects - The novel mTOR inhibitor CCI-779 (temsirolimus) induces antiproliferative effects

Li S, Liang Y, Wu M, Wang X, Fu H, Chen Y, Wang Z. Cancer Cell Int. 2013 Mar 28;13:30.