Tenidap

• Supplier: Tocris Bioscience
• Catalog: 5264
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Cas Number: 120210-48-2
• Chemical Name: (Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide
• Formula: C14H9N2O3SCl
• Molecular Weight: 320.75
• Purity: >99 %
• Description: NSAID that preferentially inhibits COX-1 (IC 50 values are < 0.03, 1.2 and > 30 μ M for COX-1, COX-2 and 5-lipoxygenase respectively). Inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes. Opener of inward rectifying hK ir 2.3 channel (EC 50 = 402 nM).

Product References

CP-66,248, a new anti-inflammatory agent, is a potent inhibitor of leukotriene B4 - CP-66,248, a new anti-inflammatory agent, is a potent inhibitor of leukotriene B4

Moilanen E, Alanko J, Asmawi MZ, Vapaatalo H. Eicosanoids. 1988;1(1):35-9.

Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 - Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2

Kirchner T, Argentieri DC, Barbone AG, Singer M, Steber M, Ansell J, Beers SA, Wachter MP, Wu W, Malloy E, Stewart A, Ritchie DM. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101.

Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying - Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying

Liu Y, Liu D, Printzenhoff D, Coghlan MJ, Harris R, Krafte DS. Eur J Pharmacol. 2002 Jan 25;435(2-3):153-60.