Teriflunomide

• Supplier: Tocris Bioscience
• Catalog: 3948
• Prices: $129.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 108605-62-5
• Chemical Name: 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
• Formula: C12H9F3N2O2
• Molecular Weight: 270.21
• Purity: >99 %
• Description: Inhibitor of dihydroorotate dehydrogenase (K d = 12 nM; K i = 179 nM). Inhibits proliferation of mitogen- or cytokine-stimulated lymphoid cells in vitro by inhibiting cell cycle progression from G 1 to S. Imunosuppressive agent. Active metabolite of leflunomide (Cat. No. 2228).

Product References

Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and - Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and

Williamson RA, Yea CM, Robson PA, Curnock AP, Gadher S, Hambleton AB, Woodward K, Bruneau JM, Hambleton P, Moss D, Thomson TA, Spinella-Jaegle S, Morand P, Courtin O, Sautes C, Westwood R, Hercend T, Kuo EA, Ruuth E. J Biol Chem. 1995 Sep 22;270(38):22467-72.

The immunosuppressive metabolite of leflunomide is a potent inhibitor of human - The immunosuppressive metabolite of leflunomide is a potent inhibitor of human

Davis JP, Cain GA, Pitts WJ, Magolda RL, Copeland RA. Biochemistry. 1996 Jan 30;35(4):1270-3.

Effects of prophylactic and therapeutic teriflunomide in transcranial magnetic - Effects of prophylactic and therapeutic teriflunomide in transcranial magnetic

Iglesias-Bregna D, Hanak S, Ji Z, Petty M, Liu L, Zhang D, McMonagle-Strucko K. J Pharmacol Exp Ther. 2013 Oct;347(1):203-11.