Tesaglitazar

• Supplier: Tocris Bioscience
• Catalog: 1316
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 251565-85-2
• Chemical Name: (S)-2-Ethoxy-3-[4-[2-(4-methanesulfonyloxyphenyl)ethoxy]phenyl]propanoicacid
• Formula: C20H24O7S
• Molecular Weight: 408.47
• Purity: >98 %
• Description: Dual-specificity PPAR α / γ agonist (IC 50 values are 0.35 and 3.8 μ M for PPAR γ and PPAR α respectively). Prevents atherosclerosis progression in E3L.CETP transgenic mice. Also reduces insulin resistance in obese Zucker rats. Orally active.

Product References

Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ - Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ

Cronet P, Petersen JF, Folmer R, Blomberg N, Sjoblom K, Karlsson U, Lindstedt EL, Bamberg K. Structure. 2001 Aug;9(8):699-706.

AZ 242, a novel PPARalpha/gamma agonist with beneficial effects on insulin - AZ 242, a novel PPARalpha/gamma agonist with beneficial effects on insulin

Ljung B, Bamberg K, Dahllof B, Kjellstedt A, Oakes ND, Ostling J, Svensson L, Camejo G. J Lipid Res. 2002 Nov;43(11):1855-63.

Synthesis and biological and structural characterization of the dual-acting - Synthesis and biological and structural characterization of the dual-acting

Ebdrup S, Pettersson I, Rasmussen HB, Deussen HJ, Frost Jensen A, Mortensen SB, Fleckner J, Pridal L, Nygaard L, Sauerberg P. J Med Chem. 2003 Apr 10;46(8):1306-17.

The dual PPARalpha/gamma agonist tesaglitazar blocks progression of pre-existing - The dual PPARalpha/gamma agonist tesaglitazar blocks progression of pre-existing

van der Hoorn JW, Jukema JW, Havekes LM, Lundholm E, Camejo G, Rensen PC, Princen HM. Br J Pharmacol. 2009 Apr;156(7):1067-75.