Tetrabenazine

• Supplier: Tocris Bioscience
• Catalog: 2822
• Prices: $139.00, $579.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 58-46-8
• Chemical Name: (3R,11bR)-rel-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one
• Formula: C19H27NO3
• Molecular Weight: 317.2
• Purity: >98 %
• Description: Potent inhibitor of vesicular monoamine uptake; depletes stores of dopamine, serotonin and noradrenalin. Binds with high affinity (IC 50 = 3.2 nM) to vesicular monoamine transporter (VMAT) in chromaffin granule membranes and displays higher affinity for VMAT2 than VMAT1. Also reported to block dopamine receptors. Causes behavioral depression; inhibits locomotor activity and produces hypothermia upon systemic administration in rats and mice.

Product References

Tetrabenazine, an amine-depleting drug, also blocks dopamine receptors in rat - Tetrabenazine, an amine-depleting drug, also blocks dopamine receptors in rat

Reches A, Burke RE, Kuhn CM, Hassan MN, Jackson VR, Fahn S. J Pharmacol Exp Ther. 1983 Jun;225(3):515-21.

Tetrabenazine-induced depletion of brain monoamines: characterization and - Tetrabenazine-induced depletion of brain monoamines: characterization and

Pettibone DJ, Totaro JA, Pflueger AB. Eur J Pharmacol. 1984 Jul 20;102(3-4):425-30.

Chimeric vesicular monoamine transporters identify structural domains that - Chimeric vesicular monoamine transporters identify structural domains that

Peter D, Vu T, Edwards RH. J Biol Chem. 1996 Feb 9;271(6):2979-86.