Tetrodotoxin

Name Tetrodotoxin
Supplier Tocris Bioscience
Catalog 0723
Prices $205.00
Sizes 1 mg
Function Type Inhibitor
Cas Number 4368-28-9
Chemical Name Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol
Formula C11H17N3O8
Molecular Weight 319.27
Description Selective inhibitor of Na + channel conductance. Binding is reversible and of high affinity (K d = 1-10 nM). Blocks in a use-dependent manner.
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Product References

Pharmacology of tetrodotoxin and saxitoxin. - Pharmacology of tetrodotoxin and saxitoxin.

Kao CY. Fed Proc. 1972 May-Jun;31(3):1117-23.

Structure-activity relations of tetrodotoxin, saxitoxin, and analogues. - Structure-activity relations of tetrodotoxin, saxitoxin, and analogues.

Kao CY. Ann N Y Acad Sci. 1986;479:52-67.

The protective action of tetrodotoxin and (+/-)-kavain on anaerobic glycolysis, - The protective action of tetrodotoxin and (+/-)-kavain on anaerobic glycolysis,

Gleitz J, Tosch C, Beile A, Peters T. Neuropharmacology. 1996;35(12):1743-52.