TFB-TBOA

• Supplier: Tocris Bioscience
• Catalog: 1069
• Prices: $129.00, $279.00
• Sizes: 1 mg, 10 mg
• Function Type: Inhibitor
• Cas Number: 480439-73-4
• Chemical Name: (3S)-3-[[3-[[4-(Trifluoromethyl)benzoyl]amino]phenyl]methoxy]-L-asparticacid
• Formula: C19H17F3N2O6
• Molecular Weight: 426.35
• Purity: >98 %
• Description: Potent and selective glial glutamate transporter EAAT1 and EAAT2 inhibitor (IC 50 values are 17, 22 and 300 nM for EAAT2, EAAT1 and EAAT3 respectively). Has no effect on EAAT4 and EAAT5, or a wide range of neuronal receptors and transporters. Attenuates glutamate-stimulated intracellular Na + elevation in astrocytes in vitro (IC50 = 43 nM). Induces severe convulsions in vivo.

Product References

Effects of a novel glutamate transporter blocker, (2S, - Effects of a novel glutamate transporter blocker, (2S,

Tsukada S, Iino M, Takayasu Y, Shimamoto K, Ozawa S. Neuropharmacology. 2005 Mar;48(4):479-91. Epub 2005 Jan 25.

Inhibitory effects of (2S, - Inhibitory effects of (2S,

Bozzo L, Chatton JY. Brain Res. 2010 Feb 26;1316:27-34.

Physical and functional interaction of NCX1 and EAAC1 transporters leading to - Physical and functional interaction of NCX1 and EAAC1 transporters leading to

Magi S, Lariccia V, Castaldo P, Arcangeli S, Nasti AA, Giordano A, Amoroso S. PLoS One. 2012;7(3):e34015.