TG 003

• Supplier: Tocris Bioscience
• Catalog: 3813
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 719277-26-6
• Chemical Name: (1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone
• Formula: C13H15NO2S
• Molecular Weight: 249.33
• Purity: >98 %
• Description: Potent, ATP-competitive inhibitor of Clk-family kinases (IC 50 values are 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μ M for mClk3). Also inhibits DYRK1A/B (IC 50 values are 24 and 34 nM respectively). Suppresses serine/arginine-rich protein phosphorylation; affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo .

Product References

Manipulation of alternative splicing by a newly developed inhibitor of Clks. - Manipulation of alternative splicing by a newly developed inhibitor of Clks.

Muraki M, Ohkawara B, Hosoya T, Onogi H, Koizumi J, Koizumi T, Sumi K, Yomoda J, Murray MV, Kimura H, Furuichi K, Shibuya H, Krainer AR, Suzuki M, Hagiwara M. J Biol Chem. 2004 Jun 4;279(23):24246-54. Epub 2004 Mar 8.

Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part - Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part

Foucourt A, Hedou D, Dubouilh-Benard C, Girard A, Taverne T, Casagrande AS, Desire L, Leblond B, Besson T. Molecules. 2014 Sep 26;19(10):15411-39.