TG 100713

• Supplier: Tocris Bioscience
• Catalog: 4336
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 925705-73-3
• Chemical Name: 3-(2,4-Diamino-6-pteridinyl)-phenol
• Formula: C12H10N6O
• Molecular Weight: 254.25
• Purity: >98 %
• Description: Inhibitor of PI3-kinase (IC 50 values are 24, 50, 165 and 215 nM for PI3K δ , γ , α and β isoforms respectively). Inhibits endothelial cell proliferation.

Product References

Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after - Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after

Doukas J, Wrasidlo W, Noronha G, Dneprovskaia E, Fine R, Weis S, Hood J, Demaria A, Soll R, Cheresh D. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19866-71. Epub 2006 Dec 15.

Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective - Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective

Palanki MS, Dneprovskaia E, Doukas J, Fine RM, Hood J, Kang X, Lohse D, Martin M, Noronha G, Soll RM, Wrasidlo W, Yee S, Zhu H. J Med Chem. 2007 Sep 6;50(18):4279-94. Epub 2007 Aug 9.