TG 4-155

• Supplier: Tocris Bioscience
• Catalog: 4264
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1164462-05-8
• Chemical Name: (2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide
• Formula: C23H26N2O4
• Molecular Weight: 394.46
• Purity: >98 %
• Description: High affinity and selective EP 2 receptor antagonist (K B values are 2.4 and 34.5 nM for EP 2 and DP 1 receptors respectively). Exhibits >500-fold selectivity for EP 2 over other prostanoid receptors. Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro .

Product References

Role of prostaglandin receptor EP2 in the regulations of cancer cell - Role of prostaglandin receptor EP2 in the regulations of cancer cell

Jiang J, Dingledine R. J Pharmacol Exp Ther. 2013 Feb;344(2):360-7.

EP2 receptor signaling pathways regulate classical activation of microglia. - EP2 receptor signaling pathways regulate classical activation of microglia.

Quan Y, Jiang J, Dingledine R. J Biol Chem. 2013 Mar 29;288(13):9293-302.