TGN 020

• Supplier: Tocris Bioscience
• Catalog: 5052
• Prices: $99.00, $419.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 51987-99-6
• Chemical Name: N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide
• Formula: C8H6N4OS
• Molecular Weight: 206.22
• Purity: >99 %
• Description: Aquaporin 4 (AQP4) channel blocker (IC 50 = 3.1 μ M). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.

Product References

Identification of aquaporin 4 inhibitors using in vitro and in silico methods. - Identification of aquaporin 4 inhibitors using in vitro and in silico methods.

Huber VJ, Tsujita M, Nakada T. Bioorg Med Chem. 2009 Jan 1;17(1):411-7.

Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces - Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces

Igarashi H, Huber VJ, Tsujita M, Nakada T. Neurol Sci. 2011 Feb;32(1):113-6.

Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. - Inhibition of aquaporin-4 significantly increases regional cerebral blood flow.

Igarashi H, Tsujita M, Suzuki Y, Kwee IL, Nakada T. Neuroreport. 2013 Apr 17;24(6):324-8.