Thapsigargin

• Supplier: Tocris Bioscience
• Catalog: 0652
• Prices: $99.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 67526-95-8
• Chemical Name: (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yloctanoate
• Formula: C34H50O12
• Molecular Weight: 650.76
• Purity: >97 %
• Description: Potent inhibitor of sarco-endoplasmic reticulum Ca 2+ -ATPases. Causes ER stress; can be used to induce autophagy in mammalian cells.

Product References

Kinetics of thapsigargin-Ca(2+)-ATPase (sarcoplasmic reticulum) interaction - Kinetics of thapsigargin-Ca(2+)-ATPase (sarcoplasmic reticulum) interaction

Davidson GA, Varhol RJ. J Biol Chem. 1995 May 19;270(20):11731-4.

A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum - A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum

Treiman M, Caspersen C, Christensen SB. Trends Pharmacol Sci. 1998 Apr;19(4):131-5.

Specific substitutions at amino acid 256 of the sarcoplasmic/endoplasmic - Specific substitutions at amino acid 256 of the sarcoplasmic/endoplasmic

Yu M, Zhong L, Rishi AK, Khadeer M, Inesi G, Hussain A. J Biol Chem. 1998 Feb 6;273(6):3542-6.

Differential effects of endoplasmic reticulum stress-induced autophagy on cell - Differential effects of endoplasmic reticulum stress-induced autophagy on cell

Ding WX, Ni HM, Gao W, Hou YF, Melan MA, Chen X, Stolz DB, Shao ZM, Yin XM. J Biol Chem. 2007 Feb 16;282(7):4702-10. Epub 2006 Nov 29.