Thiolutin

Name Thiolutin
Supplier Tocris Bioscience
Catalog 4061
Prices $149.00
Sizes 1 mg
Cas Number 87-11-6
Chemical Name N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide
Formula C8H8N2O2S2
Molecular Weight 228.28
Purity >98 %
Description Antibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC 50 = 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis.
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Product References

Mode of action of thiolutin, an inhibitor of macromolecular synthesis in - Mode of action of thiolutin, an inhibitor of macromolecular synthesis in

Jimenez A, Tipper DJ, Davies J. Antimicrob Agents Chemother. 1973 Jun;3(6):729-38.

RNA polymerase inhibitors with activity against rifampin-resistant mutants of - RNA polymerase inhibitors with activity against rifampin-resistant mutants of

O'Neill A, Oliva B, Storey C, Hoyle A, Fishwick C, Chopra I. Antimicrob Agents Chemother. 2000 Nov;44(11):3163-6.

Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in - Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in

Minamiguchi K, Kumagai H, Masuda T, Kawada M, Ishizuka M, Takeuchi T. Int J Cancer. 2001 Aug 1;93(3):307-16.