Thioperamide

• Supplier: Tocris Bioscience
• Catalog: 1567
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 106243-16-7
• Chemical Name: N-Cyclohexyl-4-(imidazol-4-yl)-1-piperidinecarbothioamide
• Formula: C15H24N4S
• Molecular Weight: 292.44
• Purity: >99 %
• Description: Potent histamine H 3 and H 4 antagonist/inverse agonist. K i values are 25 and 27 nM for human recombinant H 3 and H 4 receptors respectively. Blocks eosinophil shape change (IC 50 = 1.4 μ M) and chemotaxis (IC 50 = 519 nM) induced by histamine. Freely crosses the blood-brain barrier. Also available as part of the Histamine H 3 Receptor Tocriset™ .

Product References

Characterization of histamine H3-receptors in guinea-pig ileum with H3-selective - Characterization of histamine H3-receptors in guinea-pig ileum with H3-selective

Hew RW, Hodgkinson CR, Hill SJ. Br J Pharmacol. 1990 Nov;101(3):621-4.

Cloning and pharmacological characterization of a fourth histamine receptor - Cloning and pharmacological characterization of a fourth histamine receptor

Liu C, Ma X, Jiang X, Wilson SJ, Hofstra CL, Blevitt J, Pyati J, Li X, Chai W, Carruthers N, Lovenberg TW. Mol Pharmacol. 2001 Mar;59(3):420-6.

Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and - Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and

Ling P, Ngo K, Nguyen S, Thurmond RL, Edwards JP, Karlsson L, Fung-Leung WP. Br J Pharmacol. 2004 May;142(1):161-71.

Compared pharmacology of human histamine H3 and H4 receptors: structure-activity - Compared pharmacology of human histamine H3 and H4 receptors: structure-activity

Gbahou F, Vincent L, Humbert-Claude M, Tardivel-Lacombe J, Chabret C, Arrang JM. Br J Pharmacol. 2006 Apr;147(7):744-54.