Thioridazine hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0644
• Prices: $75.00
• Sizes: 50 mg
• Function Type: Antagonist
• Cas Number: 130-61-0
• Chemical Name: 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazinehydrochloride
• Formula: C21H26N2S2.HCl
• Molecular Weight: 407.04
• Purity: >99 %
• Description: Dopamine receptor antagonist that displays antipsychotic activity. Exhibits anticancer activity in cervical, endometrial and breast cancer cells; triggers apoptosis by targeting the PI 3-K/Akt/mTOR/p70 S6K pathway. Induces G 1 cell cycle arrest. Selective inducer of cancer stem cell (CSC) differentiation.

Product References

Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical - Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical

Kang S, Dong SM, Kim BR, Park MS, Trink B, Byun HJ, Rho SB. Apoptosis. 2012 Sep;17(9):989-97.

Identification of drugs including a dopamine receptor antagonist that selectively - Identification of drugs including a dopamine receptor antagonist that selectively

Sachlos E, Risueno RM, Laronde S, Shapovalova Z, Lee JH, Russell J, Malig M, McNicol JD, Fiebig-Comyn A, Graham M, Levadoux-Martin M, Lee JB, Giacomelli AO, Hassell JA, Fischer-Russell D, Trus MR, Foley R, Leber B, Xenocostas A, Brown ED, Collins TJ, Bhatia M. Cell. 2012 Jun 8;149(6):1284-97.