Thiostrepton

Name Thiostrepton
Supplier Tocris Bioscience
Catalog 3070
Prices $65.00
Sizes 50 mg
Cas Number 1393-48-2
Formula C72H85N19O18S5
Molecular Weight 1664.89
Purity >90 %
Description Antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.
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Product References

Thiostrepton inhibition of tRNA delivery to the ribosome. - Thiostrepton inhibition of tRNA delivery to the ribosome.

Gonzalez RL Jr, Chu S, Puglisi JD. RNA. 2007 Dec;13(12):2091-7. Epub 2007 Oct 19.

Thiostrepton selectively targets breast cancer cells through inhibition of - Thiostrepton selectively targets breast cancer cells through inhibition of

Kwok JM, Myatt SS, Marson CM, Coombes RC, Constantinidou D, Lam EW. Mol Cancer Ther. 2008 Jul;7(7):2022-32.