THIP hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3280
• Prices: $139.00
• Sizes: 50 mg
• Function Type: Antagonist
• Cas Number: 85118-33-8
• Chemical Name: 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride
• Formula: C6H8N2O2.HCl
• Molecular Weight: 176.6
• Purity: >98 %
• Description: Systemically active GABA A receptor agonist and GABA A - ρ receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.

Product References

4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. - 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP.

Krogsgaard-Larsen P, Mikkelsen H, Jacobsen P, Falch E, Curtis DR, Peet MJ, Leah JD. J Med Chem. 1983 Jun;26(6):895-900.

GABAc receptors: relatively simple transmitter -gated ion channels? - GABAc receptors: relatively simple transmitter -gated ion channels?

Johnston GA. Trends Pharmacol Sci. 1996 Sep;17(9):319-23.

Gaboxadol. Lundbeck/Merck. - Gaboxadol. Lundbeck/Merck.

Huckle R. Curr Opin Investig Drugs. 2004 Jul;5(7):766-73.