THIQ

• Supplier: Tocris Bioscience
• Catalog: 0807
• Prices: $225.00
• Sizes: 1 mg
• Function Type: Agonist
• Cas Number: 312637-48-2
• Chemical Name: N-[(1R)-1-[(4-Chlorophenyl)methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-trazol-1-ylmethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide
• Formula: C33H41ClN6O2
• Molecular Weight: 589.17
• Purity: >95 %
• Description: Potent and selective melanocortin 4 (MC 4 ) receptor agonist (IC 50 values are 1.2, 761 and 2067 nM for human MC 4 , MC 3 and MC 1 receptors respectively). Enhances intracavernosal pressure and stimulates erectile activity in rats ex copula following systemic administration.

Product References

Activation of melanocortin MC(4) receptors increases erectile activity in rats ex - Activation of melanocortin MC(4) receptors increases erectile activity in rats ex

Martin WJ, McGowan E, Cashen DE, Gantert LT, Drisko JE, Hom GJ, Nargund R, Sebhat I, Howard AD, Van der Ploeg LH, MacIntyre DE. Eur J Pharmacol. 2002 Nov 1;454(1):71-9.

Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- - Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium-

Sebhat IK, Martin WJ, Ye Z, Barakat K, Mosley RT, Johnston DB, Bakshi R, Palucki B, Weinberg DH, MacNeil T, Kalyani RN, Tang R, Stearns RA, Miller RR, Tamvakopoulos C, Strack AM, McGowan E, Cashen DE, Drisko JE, Hom GJ, Howard AD, MacIntyre DE, van der Ploeg LH, Patchett AA, Nargund RP. J Med Chem. 2002 Oct 10;45(21):4589-93.

New substituted piperazines as ligands for melanocortin receptors. Correlation to - New substituted piperazines as ligands for melanocortin receptors. Correlation to

Mutulis F, Yahorava S, Mutule I, Yahorau A, Liepinsh E, Kopantshuk S, Veiksina S, Tars K, Belyakov S, Mishnev A, Rinken A, Wikberg JE. J Med Chem. 2004 Aug 26;47(18):4613-26.