Tiagabine hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3390
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 145821-59-6
• Chemical Name: (3R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylicacidhydrochloride
• Formula: C20H25NO2S2.HCl
• Molecular Weight: 412.01
• Purity: >99 %
• Description: GABA uptake inhibitor (IC 50 = 67 nM in vivo ). Exhibits high affinity and selectivity for the GAT-1 GABA transporter. Anticonvulsant; also attenuates established dynorphin-induced allodynia in a mouse model after systemic administration.

Product References

The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the - The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the

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Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives - Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives

Dhar TG, Borden LA, Tyagarajan S, Smith KE, Branchek TA, Weinshank RL, Gluchowski C. J Med Chem. 1994 Jul 22;37(15):2334-42.

Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse - Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse

Laughlin TM, Tram KV, Wilcox GL, Birnbaum AK. J Pharmacol Exp Ther. 2002 Sep;302(3):1168-75.