| Name | TMI 1 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3675 |
| Prices | $235.00, $989.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 287403-39-8 |
| Chemical Name | (3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide |
| Formula | C17H22N2O5S2 |
| Molecular Weight | 398.49 |
| Purity | >98 % |
| Description | Adam 17 (TACE) and MMP inhibitor (IC 50 values are 3, 4.7, 6.6, 8.4, 12, 26 and 26 nM for MMP-13, MMP-2, MMP-1, ADAM 17, MMP-9, MMP-7 and MMP-14, respectively). Suppresses TNF- α production in an acute LPS-mouse model. Reduces severity score in an in vivo model of rheumatoid arthritis. Displays selective cytotoxicity to tumor cells and cancer stem cells in vitro . Induces tumor apoptosis in a breast cancer in vivo model. Orally bioavailable. |
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