TMPyP4 tosylate

• Supplier: Tocris Bioscience
• Catalog: 2438
• Prices: $95.00
• Sizes: 50 mg
• Cas Number: 36951-72-1
• Chemical Name: 5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)porphyrintetra(p-toluenesulfonate)
• Formula: C72H66N8O12S4
• Molecular Weight: 1363.6
• Purity: >95 %
• Description: Cationic porphyrin; inhibits human telomerase. Stacks with G tetrads to stabilize quadruplex DNA. Inhibits cell proliferation and induces cell death in three myeloma cell lines. Activity results in telomere shortening at concentrations between 1 and 5 μ M.

Product References

Effect of telomere and telomerase interactive agents on human tumor and normal - Effect of telomere and telomerase interactive agents on human tumor and normal

Rha SY, Izbicka E, Lawrence R, Davidson K, Sun D, Moyer MP, Roodman GD, Hurley L, Von Hoff D. Clin Cancer Res. 2000 Mar;6(3):987-93.

Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in - Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in

Shammas MA, Shmookler Reis RJ, Akiyama M, Koley H, Chauhan D, Hideshima T, Goyal RK, Hurley LH, Anderson KC, Munshi NC. Mol Cancer Ther. 2003 Sep;2(9):825-33.