TNP

• Supplier: Tocris Bioscience
• Catalog: 1509
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 519178-28-0
• Chemical Name: N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine
• Formula: C20H16F3N7O2
• Molecular Weight: 443.38
• Purity: >97 %
• Description: Reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC 50 = 0.47 μ M for inhibition of InsP 7 formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC 50 = 10.2 μ M). Binds to the ATP binding site of IP3K (K i = 4.3 μ M).

Product References

Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. - Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase.

Chang YT, Choi G, Bae YS, Burdett M, Moon HS, Lee JW, Gray NS, Schultz PG, Meijer L, Chung SK, Choi KY, Suh PG, Ryu SH. Chembiochem. 2002 Sep 2;3(9):897-901.

Characterization of a selective inhibitor of inositol hexakisphosphate kinases: - Characterization of a selective inhibitor of inositol hexakisphosphate kinases:

Padmanabhan U, Dollins DE, Fridy PC, York JD, Downes CP. J Biol Chem. 2009 Apr 17;284(16):10571-82.