TNP-ATP triethylammonium salt

Name TNP-ATP triethylammonium salt
Supplier Tocris Bioscience
Catalog 3946
Prices $259.00
Sizes 5 mg
Function Type Antagonist
Cas Number 61368-63-6
Chemical Name 2',3'-O-(2,4,6-Trinitrophenyl)adenosine-5'-triphosphatetetra(triethylammonium)salt
Formula C16H13N8O19P3.C24H64N4
Molecular Weight 1123.04
Purity >95 %
Description High affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X 1 , P2X 3 and heteromeric P2X 2/3 receptors with IC 50 values of 6, 0.9 and 7 nM respectively. Displays 1000-fold selectivity over P2X 2 , P2X 4 and P2X 7 .
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Product References

2',3'-O-(2,4,6- trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP)--a nanomolar - 2',3'-O-(2,4,6- trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP)--a nanomolar

Lewis CJ, Surprenant A, Evans RJ. Br J Pharmacol. 1998 Aug;124(7):1463-6.

Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, - Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1,

Virginio C, Robertson G, Surprenant A, North RA. Mol Pharmacol. 1998 Jun;53(6):969-73.