| Name | Toceranib |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5390 |
| Prices | $249.00, $1,025.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 356068-94-5 |
| Chemical Name | 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide |
| Formula | C22H25FN4O2 |
| Molecular Weight | 396.46 |
| Purity | >98 % |
| Description | Potent ATP-competitive PDGFR and VEGFR inhibitor (K i = 5 and 6 nM, respectively); inhibits phosphorylation of c-Kit and suppresses the growth of mast cell lines expressing mutant Kit, inducing cell cycle arrest and apoptosis. Also inhibits FGFR1 (K i = 0.5 μ M). Effective in vivo . |
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