| Name | Tolcapone |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1684 |
| Prices | $75.00, $315.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 134308-13-7 |
| Chemical Name | (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone |
| Formula | C14H11NO5 |
| Molecular Weight | 273.24 |
| Purity | >99 % |
| Description | COMT inhibitor. Inhibits both brain and peripheral COMT. Also binds transthyretin (TTR) with high affinity (K d1 and K d2 values are 21 and 58 nM, respectively). Inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro . Stabilizes TTR in mice and humans in vivo . Orally bioavailable. |
| Supplier Page | Shop |
Nilvebrant L, Andersson KE, Gillberg PG, Stahl M, Sparf B. Eur J Pharmacol. 1997 May 30;327(2-3):195-207.
Nilvebrant L. Life Sci. 2001 Apr 27;68(22-23):2549-56.