Topiramate

• Supplier: Tocris Bioscience
• Catalog: 2011
• Prices: $89.00, $375.00
• Sizes: 10 mg, 50 mg
• Cas Number: 97240-79-4
• Chemical Name: 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranosesulfamate
• Formula: C12H21NO8S
• Molecular Weight: 339.36
• Purity: >99 %
• Description: Anticonvulsant. Antagonizes GluR5 kainate receptors (IC 50 = 0.46 μ M), acts as a positive allosteric modulator of GABA A receptor-mediated currents, inhibits Na v channels (IC 50 = 48.9 μ M) and inhibits L-type Ca 2+ channels. Also inhibits carbonic anhydrase (CA) (K i values are 0.1 and 0.2 μ M at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.

Product References

Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule - Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule

Zona C, Ciotti MT, Avoli M. Neurosci Lett. 1997 Aug 15;231(3):123-6.

Topiramate as an inhibitor of carbonic anhydrase isoenzymes. - Topiramate as an inhibitor of carbonic anhydrase isoenzymes.

Dodgson SJ, Shank RP, Maryanoff BE. Epilepsia. 2000;41 Suppl 1:S35-9.

Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by - Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by

Gryder DS, Rogawski MA. J Neurosci. 2003 Aug 6;23(18):7069-74.

Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate - Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate

Kaminski RM, Banerjee M, Rogawski MA. Neuropharmacology. 2004 Jun;46(8):1097-104.