Topotecan hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 5541
• Prices: $59.00, $185.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 119413-54-6
• Chemical Name: 10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dionehydrochloride
• Formula: C23H23N3O5.HCl
• Molecular Weight: 457.91
• Purity: >98 %
• Description: DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis ALL; downregulates B-Myb and MycN expression in neuroblastoma cells. Water-soluble analog of Camptothecin (Cat. No. 1100). Orally bioavailable.

Product References

In vitro and in vivo activity of topotecan against human B-lineage acute - In vitro and in vivo activity of topotecan against human B-lineage acute

Uckun FM, Stewart CF, Reaman G, Chelstrom LM, Jin J, Chandan-Langlie M, Waddick KG, White J, Evans WE. Blood. 1995 May 15;85(10):2817-28.

Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I - Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I

Schellens JH, Creemers GJ, Beijnen JH, Rosing H, de Boer-Dennert M, McDonald M, Davies B, Verweij J. Br J Cancer. 1996 May;73(10):1268-71.

A chemical screen identifies the chemotherapeutic drug topotecan as a specific - A chemical screen identifies the chemotherapeutic drug topotecan as a specific

Sottile F, Gnemmi I, Cantilena S, D'Acunto WC, Sala A. Oncotarget. 2012 May;3(5):535-45.