Torcetrapib

• Supplier: Tocris Bioscience
• Catalog: 4562
• Prices: $249.00, $1,025.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 262352-17-0
• Chemical Name: (2R,4S)-4-[[[3,5-bis(Trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline-1-carboxylicacidethylester
• Formula: C26H25F9N2O4
• Molecular Weight: 600.47
• Purity: >99 %
• Description: Inhibitor of cholesteryl ester transfer protein (CETP). Also impairs endothelial function in vivo ; induces hypertension and inhibits acetylcholine-induced vasodilation in rabbit central ear artery.

Product References

Torcetrapib-induced blood pressure elevation is independent of CETP inhibition - Torcetrapib-induced blood pressure elevation is independent of CETP inhibition

Forrest MJ, Bloomfield D, Briscoe RJ, Brown PN, Cumiskey AM, Ehrhart J, Hershey JC, Keller WJ, Ma X, McPherson HE, Messina E, Peterson LB, Sharif-Rodriguez W, Siegl PK, Sinclair PJ, Sparrow CP, Stevenson AS, Sun SY, Tsai C, Vargas H, Walker M 3rd, West SH, White V, Woltmann RF. Br J Pharmacol. 2008 Aug;154(7):1465-73.

Torcetrapib produces endothelial dysfunction independent of cholesteryl ester - Torcetrapib produces endothelial dysfunction independent of cholesteryl ester

Connelly MA, Parry TJ, Giardino EC, Huang Z, Cheung WM, Chen C, Cools F, Van der Linde H, Gallacher DJ, Kuo GH, Sarich TC, Demarest KT, Damiano BP. J Cardiovasc Pharmacol. 2010 May;55(5):459-68.