Torin 1

• Supplier: Tocris Bioscience
• Catalog: 4184
• Prices: $249.00, $1,025.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1222998-36-8
• Chemical Name: 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
• Formula: C35H28F3N5O2
• Molecular Weight: 607.62
• Purity: >98 %
• Description: Potent and selective mTOR inhibitor (IC 50 = 2 - 10 nM for mTORC1 and mTORC2). Displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34. Induces autophagy in HeLa cells.

Product References

The pharmacology of mTOR inhibition. - The pharmacology of mTOR inhibition.

Guertin DA, Sabatini DM. Sci Signal. 2009 Apr 21;2(67):pe24.

An ATP-competitive mammalian target of rapamycin inhibitor reveals - An ATP-competitive mammalian target of rapamycin inhibitor reveals

Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS. J Biol Chem. 2009 Mar 20;284(12):8023-32.

Discovery of - Discovery of

Liu Q, Chang JW, Wang J, Kang SA, Thoreen CC, Markhard A, Hur W, Zhang J, Sim T, Sabatini DM, Gray NS. J Med Chem. 2010 Oct 14;53(19):7146-55.

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. - mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.

Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM. Cell. 2011 Aug 5;146(3):408-20.