Toyocamycin

• Supplier: Tocris Bioscience
• Catalog: 4248
• Prices: $75.00, $315.00
• Sizes: 10 mg, 50 mg
• Cas Number: 606-58-6
• Chemical Name: 4-Amino-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
• Formula: C12H13N5O4
• Molecular Weight: 291.26
• Purity: >98 %
• Description: Adenosine analog; antifungal antibiotic. Inhibits RNA self-cleavage in HEK79 cells and PI 3-kinase activity in A431 epidermoid carcinoma cell membrane fractions. Also inhibits thapsigargin-induced XBP1-luciferase activation and induces apoptosis in multiple myeloma cell lines.

Product References

Inhibition of phosphatidylinositol kinase by toyocamycin. - Inhibition of phosphatidylinositol kinase by toyocamycin.

Nishioka H, Sawa T, Hamada M, Shimura N, Imoto M, Umezawa K. J Antibiot (Tokyo). 1990 Dec;43(12):1586-9.

Identification of inhibitors of ribozyme self-cleavage in mammalian cells via - Identification of inhibitors of ribozyme self-cleavage in mammalian cells via

Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC. RNA. 2006 May;12(5):797-806. Epub 2006 Mar 23.

Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as - Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as

Ri M, Tashiro E, Oikawa D, Shinjo S, Tokuda M, Yokouchi Y, Narita T, Masaki A, Ito A, Ding J, Kusumoto S, Ishida T, Komatsu H, Shiotsu Y, Ueda R, Iwawaki T, Imoto M, Iida S. Blood Cancer J. 2012 Jul;2(7):e79.