TP 003

• Supplier: Tocris Bioscience
• Catalog: 5270
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 628690-75-5
• Chemical Name: 2',4-Difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]-pyridin-3-yl]-[1,1'-biphenyl]-2-carbonitrile
• Formula: C23H16F3N3O
• Molecular Weight: 407.39
• Purity: >98 %
• Description: Functionally selective GABA A receptor ( α 3 subtype) partial agonist. Exhibits affinity for the benzodiazepine binding site on human GABA A receptors. Potentiates the GABA ( α 3 subtype) response selectively with high efficacy. Produces anxiolytic-like effects in rodent behavioral models of anxiety.

Product References

Evidence for a significant role of alpha 3-containing GABAA receptors in - Evidence for a significant role of alpha 3-containing GABAA receptors in

Dias R, Sheppard WF, Fradley RL, Garrett EM, Stanley JL, Tye SJ, Goodacre S, Lincoln RJ, Cook SM, Conley R, Hallett D, Humphries AC, Thompson SA, Wafford KA, Street LJ, Castro JL, Whiting PJ, Rosahl TW, Atack JR, McKernan RM, Dawson GR, Reynolds DS. J Neurosci. 2005 Nov 16;25(46):10682-8.

Contribution of GABA(A) receptors containing alpha3 subunits to the - Contribution of GABA(A) receptors containing alpha3 subunits to the

Fischer BD, Atack JR, Platt DM, Reynolds DS, Dawson GR, Rowlett JK. Psychopharmacology (Berl). 2011 May;215(2):311-9.