TP 064

• Supplier: Tocris Bioscience
• Catalog: 4414
• Prices: $135.00, $569.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Chemical Name: N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide
• Formula: C28H34N4O2
• Molecular Weight: 458.6
• Purity: >98 %
• Description: Potent and selective PRMT4 inhibitor; inhibits methylation of H3 (1-25) and MED12 (IC 50 values are <10 and 43 nM, respectively). Exhibits >100-fold selectivity over other histone methyltransferases and non-epigenetic targets.

Product References

Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and - Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and

Birrell MA, Hardaker E, Wong S, McCluskie K, Catley M, De Alba J, Newton R, Haj-Yahia S, Pun KT, Watts CJ, Shaw RJ, Savage TJ, Belvisi MG. Am J Respir Crit Care Med. 2005 Oct 15;172(8):962-71. Epub 2005 Jul 7.

Attenuation of murine collagen-induced arthritis by a novel, potent, selective - Attenuation of murine collagen-induced arthritis by a novel, potent, selective

Podolin PL, Callahan JF, Bolognese BJ, Li YH, Carlson K, Davis TG, Mellor GW, Evans C, Roshak AK. J Pharmacol Exp Ther. 2005 Jan;312(1):373-81. Epub 2004 Aug 17.

IkappaB kinase-2-independent and -dependent inflammation in airway disease - IkappaB kinase-2-independent and -dependent inflammation in airway disease

Birrell MA, Wong S, Hardaker EL, Catley MC, McCluskie K, Collins M, Haj-Yahia S, Belvisi MG. Mol Pharmacol. 2006 Jun;69(6):1791-800. Epub 2006 Mar 3.