TPEN

• Supplier: Tocris Bioscience
• Catalog: 2559
• Prices: $109.00
• Sizes: 100 mg
• Cas Number: 16858-02-9
• Chemical Name: N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine
• Formula: C26H28N6
• Molecular Weight: 424.54
• Purity: >98 %
• Description: Heavy metal chelator. Reacts with both Zn-proteome and Zn-metallothionein (MT) in LLC-PK 1 cells; acts as an intracellular chelator of proteomic Zn 2+ . Activity decreases intracellular zinc levels, and induces apoptosis in HeLa and cultured human retinal pigment epithelium (RPE) cells. Cell permeable.

Product References

Role of cellular zinc in programmed cell death: temporal relationship between - Role of cellular zinc in programmed cell death: temporal relationship between

Chimienti F, Seve M, Richard S, Mathieu J, Favier A. Biochem Pharmacol. 2001 Jul 1;62(1):51-62.

Zinc binding ligands and cellular zinc trafficking: apo-metallothionein, - Zinc binding ligands and cellular zinc trafficking: apo-metallothionein,

Rana U, Kothinti R, Meeusen J, Tabatabai NM, Krezoski S, Petering DH. J Inorg Biochem. 2008 Mar;102(3):489-99.

Validation of TPEN as a zinc chelator in fluorescence probing of calcium in cells - Validation of TPEN as a zinc chelator in fluorescence probing of calcium in cells

Matias CM, Sousa JM, Quinta-Ferreira ME, Arif M, Burrows HD. J Fluoresc. 2010 Jan;20(1):377-80.