TPMPA

• Supplier: Tocris Bioscience
• Catalog: 4309
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 182485-36-5
• Chemical Name: (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinicacid
• Formula: C6H12NO2P
• Molecular Weight: 161.14
• Purity: >98 %
• Description: A selective, competitive GABA A - ρ antagonist with only minimal effects on GABA A and GABA B receptors (K b values are 2.1 μ M (antagonist), 320 μ M (antagonist) and EC 50 ~ 500 μ M (weak agonist) respectively). Displays 8-fold selectivity for human recombinant ρ 1 receptors over ρ 2 receptors.

Product References

Design and in vitro pharmacology of a selective gamma-aminobutyric acidC receptor - Design and in vitro pharmacology of a selective gamma-aminobutyric acidC receptor

Ragozzino D, Woodward RM, Murata Y, Eusebi F, Overman LE, Miledi R. Mol Pharmacol. 1996 Oct;50(4):1024-30.

GABA(C) receptor antagonists differentiate between human rho1 and rho2 receptors - GABA(C) receptor antagonists differentiate between human rho1 and rho2 receptors

Chebib M, Mewett KN, Johnston GA. Eur J Pharmacol. 1998 Sep 18;357(2-3):227-34.

The involvement of GABA-C receptors in paired-pulse depression of inhibitory - The involvement of GABA-C receptors in paired-pulse depression of inhibitory

Xu JY, Yang B, Sastry BR. Exp Neurol. 2009 Mar;216(1):243-6.