Tracazolate hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4233
• Prices: $89.00, $375.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 1135210-68-2
• Chemical Name: 4-(Butylamino)-1-ethyl-6-methyl1H-pyrazolo[3,4b]pyridine-5-ethylcarboxylatehydrochloride
• Formula: C16H24N4O2.HCl
• Molecular Weight: 340.85
• Purity: >99 %
• Description: Subtype-selective GABA A receptor modulator. Can potentiate or inhibit recombinant GABA A function depending on subunit combination. Enhances native GABA A receptor function and is anxiolytic following systemic administration in vivo .

Product References

Enhancement of benzodiazepine and GABA binding by the novel anxiolytic, - Enhancement of benzodiazepine and GABA binding by the novel anxiolytic,

Meiners BA, Salama AI. Eur J Pharmacol. 1982 Mar 12;78(3):315-22.

Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic - Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic

Patel JB, Malick JB. Eur J Pharmacol. 1982 Mar 12;78(3):323-33.

Tracazolate reveals a novel type of allosteric interaction with recombinant - Tracazolate reveals a novel type of allosteric interaction with recombinant

Thompson SA, Wingrove PB, Connelly L, Whiting PJ, Wafford KA. Mol Pharmacol. 2002 Apr;61(4):861-9.