TRAM 39

• Supplier: Tocris Bioscience
• Catalog: 2946
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 197525-99-8
• Chemical Name: 2-Chloro-α,α-diphenylbenzeneacetonitrile
• Formula: C20H14ClN
• Molecular Weight: 303.78
• Purity: >99 %
• Description: Potent intermediate conductance Ca 2+ -activated K + channel (K Ca 3.1) blocker (K d = 60 nM). Has no effect on cytochrome p450 activity. Inhibits I-EBIO -stimulated increases in rat artery membrane potential ex vivo . Also diminishes LPS-induced cryptidin (mammalian α -defensin) release from paneth cells in vitro .

Product References

Design of a potent and selective inhibitor of the intermediate-conductance - Design of a potent and selective inhibitor of the intermediate-conductance

Wulff H, Miller MJ, Hansel W, Grissmer S, Cahalan MD, Chandy KG. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8151-6.

Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a - Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a

Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ. J Biol Chem. 2002 Feb 1;277(5):3793-800. Epub 2001 Nov 27.

Impaired small-conductance Ca2+-activated K+ channel-dependent EDHF responses in - Impaired small-conductance Ca2+-activated K+ channel-dependent EDHF responses in

Burnham MP, Johnson IT, Weston AH. Br J Pharmacol. 2006 Jun;148(4):434-41. Epub 2006 May 8.