| Name | Tramiprosate |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4952 |
| Prices | $59.00 |
| Sizes | 50 mg |
| Cas Number | 3687-18-1 |
| Chemical Name | 3-Amino-1-propanesulfonicacid |
| Formula | C3H9NO3S |
| Molecular Weight | 139.17 |
| Description | Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (A β ) and maintains A β in a non-fibrillar form. Decreases A β 42-induced neuronal death and inhibits amyloid deposition in vitro . Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo . |
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Fariello RG, Golden GT, Pisa M. Neurology. 1982 Mar;32(3):241-5.
Gervais F, Paquette J, Morissette C, Krzywkowski P, Yu M, Azzi M, Lacombe D, Kong X, Aman A, Laurin J, Szarek WA, Tremblay P. Neurobiol Aging. 2007 Apr;28(4):537-47. Epub 2006 May 3.