Tranilast

• Supplier: Tocris Bioscience
• Catalog: 3619
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Cas Number: 53902-12-8
• Chemical Name: 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoicacid
• Formula: C18H17NO5
• Molecular Weight: 327.34
• Purity: >99 %
• Description: Antiallergic via inhibition of chemical mediator release from mast cells. Shown to be an effective inhibitor of angiogenesis. Demonstrated to antagonize the effects of angiotensin II on human arteries, possibly by an interaction at the level of the AT 1 receptor. Inhibits TRPV2-mediated responses; binds to A β 40 monomers and increases A β 40 fibrillation.

Product References

Tranilast restores cytokine-induced nitric oxide production against - Tranilast restores cytokine-induced nitric oxide production against

Hishikawa K, Nakaki T, Hirahashi J, Marumo T, Saruta T. J Cardiovasc Pharmacol. 1996 Aug;28(2):200-7.

Tranilast inhibits the proliferation, chemotaxis and tube formation of human - Tranilast inhibits the proliferation, chemotaxis and tube formation of human

Isaji M, Miyata H, Ajisawa Y, Takehana Y, Yoshimura N. Br J Pharmacol. 1997 Nov;122(6):1061-6.

Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin - Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin

Jin D, Takai S, Shiota N, Miyazaki M. Eur J Pharmacol. 1998 Nov 20;361(2-3):199-205.

Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic - Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic

Hisanaga E, Nagasawa M, Ueki K, Kulkarni RN, Mori M, Kojima I. Diabetes. 2009 Jan;58(1):174-84.

Tranilast binds to abeta monomers and promotes abeta fibrillation. - Tranilast binds to abeta monomers and promotes abeta fibrillation.

Connors CR, Rosenman DJ, Lopes DH, Mittal S, Bitan G, Sorci M, Belfort G, Garcia A, Wang C. Biochemistry. 2013 Jun 11;52(23):3995-4002.