Tranylcypromine hydrochloride

Name Tranylcypromine hydrochloride
Supplier Tocris Bioscience
Catalog 1098
Prices $59.00
Sizes 50 mg
Function Type Inhibitor
Cas Number 1986-47-6
Chemical Name (±)-trans-2-Phenylcyclopropylaminehydrochloride
Formula C9H11N.HCl
Molecular Weight 169.65
Purity >98 %
Description Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Inhibits histone demethylation. In combination with CHIR 99021 (Cat. No. 4423), enables reprogramming of mouse embryonic fibroblasts transduced by only two factors, Oct4 and Klf4, into induced pluripotent stem (iPS) cells.
Supplier Page Shop

Product References

Histone H3 lysine 4 demethylation is a target of nonselective antidepressive - Histone H3 lysine 4 demethylation is a target of nonselective antidepressive

Lee MG, Wynder C, Schmidt DM, McCafferty DG, Shiekhattar R. Chem Biol. 2006 Jun;13(6):563-7.

trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone - trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone

Schmidt DM, McCafferty DG. Biochemistry. 2007 Apr 10;46(14):4408-16. Epub 2007 Mar 17.

Generation of human-induced pluripotent stem cells in the absence of exogenous - Generation of human-induced pluripotent stem cells in the absence of exogenous

Li W, Zhou H, Abujarour R, Zhu S, Young Joo J, Lin T, Hao E, Scholer HR, Hayek A, Ding S. Stem Cells. 2009 Dec;27(12):2992-3000.