Trap 101

• Supplier: Tocris Bioscience
• Catalog: 3852
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1216621-00-9
• Chemical Name: 1-[1-(Cyclooctylmethyl)-1,2,3,6-tetrahydro-5-(hydroxymethyl)-4-pyridinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-onehydrochloride
• Formula: C24H35N3O2.HCl
• Molecular Weight: 434.02
• Purity: >98 %
• Description: Potent and selective nociceptin/orphanin FQ (NOP) receptor antagonist (pA 2 = 7.75). Displays selectivity for NOP receptors over classical opioid receptors (pK i values are 8.65, 6.60, 6.14 and < 5 for NOP, μ -, κ -, and δ -opioid receptors respectively). Attenuates motor deficits in a rat model of Parkinson's Disease. Active in vivo .

Product References

Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin - Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin

Trapella C, Guerrini R, Piccagli L, Calo' G, Carra' G, Spagnolo B, Rubini S, Fanton G, Hebbes C, McDonald J, Lambert DG, Regoli D, Salvadori S. Bioorg Med Chem. 2006 Feb 1;14(3):692-704. Epub 2005 Oct 3.

The novel nociceptin/orphanin FQ receptor antagonist Trap-101 alleviates - The novel nociceptin/orphanin FQ receptor antagonist Trap-101 alleviates

Marti M, Trapella C, Morari M. J Neurochem. 2008 Dec;107(6):1683-96.