TRAP-6

Name TRAP-6
Supplier Tocris Bioscience
Catalog 2508
Prices $199.00
Sizes 5 mg
Function Type Agonist
Cas Number 141136-83-6
Formula C34H56N10O9
Molecular Weight 748.88
Description Peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR 1 ) that acts as a PAR 1 agonist. Stimulates platelet aggregation (EC 50 = 0.8 μ M), promotes intracellular Ca 2+ mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation in vitro .
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Product References

Structure-function relationships in the activation of platelet thrombin receptors - Structure-function relationships in the activation of platelet thrombin receptors

Vassallo RR Jr, Kieber-Emmons T, Cichowski K, Brass LF. J Biol Chem. 1992 Mar 25;267(9):6081-5.

PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling - PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling

Kaufmann R, Patt S, Kraft R, Zieger M, Henklein P, Neupert G, Nowak G. J Neurooncol. 1999 Apr;42(2):131-6.

Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP - Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP

Hunter RW, Mackintosh C, Hers I. J Biol Chem. 2009 May 1;284(18):12339-48.