Treprostinil

• Supplier: Tocris Bioscience
• Catalog: 4734
• Prices: $235.00
• Sizes: 10 mg
• Cas Number: 81846-19-7
• Chemical Name: 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]aceticacid
• Formula: C23H34O5
• Molecular Weight: 390.51
• Purity: >98 %
• Description: Potent prostacyclin (PGI 2 ) analog (EC 50 values are 0.6, 1.9 and 6.2 nM at DP 1 , IP and EP 2 receptors respectively). Causes vasodilation of human pulmonary arteries and inhibits NF κ B nuclear translocation in human alveolar macrophages in vitro .

Product References

The prostacyclin analogue treprostinil blocks NFkappaB nuclear translocation in - The prostacyclin analogue treprostinil blocks NFkappaB nuclear translocation in

Raychaudhuri B, Malur A, Bonfield TL, Abraham S, Schilz RJ, Farver CF, Kavuru MS, Arroliga AC, Thomassen MJ. J Biol Chem. 2002 Sep 6;277(36):33344-8. Epub 2002 Jun 24.

Treprostinil potentiates the positive inotropic effect of catecholamines in adult - Treprostinil potentiates the positive inotropic effect of catecholamines in adult

Fontana M, Olschewski H, Olschewski A, Schluter KD. Br J Pharmacol. 2007 Jul;151(6):779-86. Epub 2007 May 29.

Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and - Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and

Whittle BJ, Silverstein AM, Mottola DM, Clapp LH. Biochem Pharmacol. 2012 Jul 1;84(1):68-75.