Trequinsin hydrochloride

Name Trequinsin hydrochloride
Supplier Tocris Bioscience
Catalog 5349
Prices $259.00
Sizes 10 mg
Function Type Inhibitor
Cas Number 78416-81-6
Chemical Name 2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-onehydrochloride
Formula C24H27N3O3.HCl
Molecular Weight 441.95
Purity >97 %
Description Extremely potent inhibitor of cGMP-inhibited phosphodiesterase (PDE3; IC 50 = 250 pM). Potently inhibits arachidonic acid-induced aggregation of human platelets (IC 50 = 50 pM). Orally active antihypertensive agent; reduces systemic blood pressure in both normotensive and hypertensive animal models.
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Product References

HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced - HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced

Ruppert D, Weithmann KU. Life Sci. 1982 Nov 8;31(19):2037-43.

Trequinsin, a potent new antihypertensive vasodilator in the series of - Trequinsin, a potent new antihypertensive vasodilator in the series of

Lal B, Dohadwalla AN, Dadkar NK, D'Sa A, de Souza NJ. J Med Chem. 1984 Nov;27(11):1470-80.

Role of plasma adenosine in the antiplatelet action of HL 725, a potent inhibitor - Role of plasma adenosine in the antiplatelet action of HL 725, a potent inhibitor

Agarwal KC, Buckley RS, Parks RE Jr. Thromb Res. 1987 Jul 15;47(2):191-200.