Trichostatin A

Name Trichostatin A
Supplier Tocris Bioscience
Catalog 2472
Prices $185.00
Sizes 1 mg
Function Type Inhibitor
Cas Number 58880-19-6
Chemical Name (2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Formula C17H22N2O3
Molecular Weight 302.37
Purity >98 %
Description Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells.
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Product References

Potent and specific inhibition of mammalian histone deacetylase both in vivo and - Potent and specific inhibition of mammalian histone deacetylase both in vivo and

Yoshida M, Kijima M, Akita M, Beppu T. J Biol Chem. 1990 Oct 5;265(28):17174-9.

Inhibition of mitogenesis in Balb/c-3T3 cells by Trichostatin A. Multiple - Inhibition of mitogenesis in Balb/c-3T3 cells by Trichostatin A. Multiple

Wharton W, Savell J, Cress WD, Seto E, Pledger WJ. J Biol Chem. 2000 Oct 27;275(43):33981-7.

Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity - Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity

Vigushin DM, Ali S, Pace PE, Mirsaidi N, Ito K, Adcock I, Coombes RC. Clin Cancer Res. 2001 Apr;7(4):971-6.

Reprogramming primordial germ cells into pluripotent stem cells. - Reprogramming primordial germ cells into pluripotent stem cells.

Durcova-Hills G, Tang F, Doody G, Tooze R, Surani MA. PLoS One. 2008;3(10):e3531.